Dimethylformamide → 1-(3-Cyano-4-oxo-4H-1-benzopyran-6-yl)ethyl acetate

HRID 2083227노트

반응식

HRID 2083227 반응식
Br[CH:2]([C:4]1[CH:5]=[CH:6][C:7]2[O:12][CH:11]=[C:10]([C:13]#[N:14])[C:9](=[O:15])[C:8]=2[CH:16]=1)[CH3:3].[C:17]([O-:20])(=[O:19])[CH3:18].[Na+].CN(C)C=O>O>[C:17]([O:20][CH:2]([C:4]1[CH:5]=[CH:6][C:7]2[O:12][CH:11]=[C:10]([C:13]#[N:14])[C:9](=[O:15])[C:8]=2[CH:16]=1)[CH3:3])(=[O:19])[CH3:18]

참가 물질

5

반응물 3

HCID 6228DimethylformamideHCID 517045Sodium AcetateHCID 203582246-(1-Bromoethyl)-4-oxo-4H-1-benzopyran-3-carbonitrile

생성물 1

HCID 203582201-(3-Cyano-4-oxo-4H-1-benzopyran-6-yl)ethyl acetate

시약·촉매·용매 1

HCID 962Water용매

반응 조건

온도
70 °C

실험 절차

A mixture of 5.56 parts of 6-(1-bromoethyl)-4-oxo-4H-1-benzopyran-3-carbonitrile, 1.640 parts of anhydrous sodium acetate and 8 parts by volume of dimethylformamide is heated at 70° C under stirring for 50 minutes. After cooling, the reaction mixture is poured into 100 parts by volume of water to give precipitates, which are collected and recrystallized from ethanol and subsequently ethyl acetate. The procedure yields 2.90 parts of 6-(1-acetoxy-ethyl)-4-oxo-4H-1-benzopyran-3-carbonitrile. Melting point: 148°-149° C

후처리

  1. temperatureAfter cooling
  2. customto give
  3. customprecipitates
  4. customwhich are collected
  5. customrecrystallized from ethanol and subsequently ethyl acetate

출처 및 근거

ORD 기록
ord-1f04cdfe96ca4084b6c7976e3ff36443
출처 데이터셋
uspto-grants-1978_04
특허 번호
US04085116

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