Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Oxalyl chloride → 2-Methoxy-4,6-bis(trifluoromethyl)benzoyl chloride
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Oxalyl chloride | HCID 65578 | — |
| 반응물 | 2-Methoxy-4,6-bis(trifluoromethyl)benzoic acid | HCID 2741287 | — |
| 촉매 | Dimethylformamide | HCID 6228 | — |
| 용매 | Dichloromethane | HCID 6344 | — |
| 생성물 | 2-Methoxy-4,6-bis(trifluoromethyl)benzoyl chloride | HCID 17999345 | 109.3% |
반응 단계
To a solution of 2-(methyloxy)-4,6-bis(trifluoromethyl)benzoic acid (20.2 g; 70.14 mmol) in dry DCM (400 mL), at 0° C., was added dropwise oxalyl chloride (13.4 mL; 154.31 mmol) followed by dry DMF (5 drops). The reaction was allowed to reach room temperature. After overnight stirring the solvent was evaporated in vacuo to get the title product (23.5 g) as a yellow slurry used without further purification.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US07745642B2 |
| 출처 데이터셋 | uspto-grants-2010_06 |
| ORD ID | ord-865399f9efde4960829c7c9e0ae9bec4 |
| 출처 메모 | uspto-grants-2010_06 |