Acetic Acid → 2-Naphthalenecarboxamide
반응식
C(O)(=O)C.O[C:6]1[C:15]2[C:10](=[CH:11][CH:12]=[CH:13][CH:14]=2)[C:9]([N+]([O-])=O)=[CH:8][C:7]=1[C:19]([NH:21]CCCOC1C=CC(C(CC)(C)C)=CC=1C(CC)(C)C)=[O:20]>[Fe].O>[CH:6]1[C:15]2[C:10](=[CH:11][CH:12]=[CH:13][CH:14]=2)[CH:9]=[CH:8][C:7]=1[C:19]([NH2:21])=[O:20]참가 물질
5
실험 절차
In 500 ml of a 90% acetic acid aqueous solution, 50 g of 1-hydroxy-4-nitro-N-[γ-(2,4-di-tert-amylphenoxy)propyl]-2-naphthamide was reduced with 50 g of iron as a reducing agent. The reaction mixture was added to water and then was extracted with ethyl acetate. After evaporating off the ethyl acetate, the crystals were recrystallized from ligroin to provide 40 g of 1-hydroxy-4-amino-N-[γ-2,4-di-tert-amylphenoxy)propyl]-2-naphthamide having a melting point of 132° to 133° C.
후처리
- extractionwas extracted with ethyl acetate
- customAfter evaporating off the ethyl acetate
- customthe crystals were recrystallized from ligroin
출처 및 근거
- ORD 기록
- ord-95da9b2771734a05956ca70091cf8a17
- 출처 데이터셋
- uspto-grants-1978_04
- 특허 번호
- US04086094
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