Benzene → 2-[1-beta-Chloroethyl-3-(5-bromothiazol-2-yl)ureido]acetaldehyde

HRID 2083620노트

반응식

HRID 2083620 반응식
[Br:1][C:2]1[S:6][C:5]([N:7]=[C:8]=[O:9])=[N:4][CH:3]=1.C1C=CC=CC=1.[Cl:16][CH2:17][CH2:18][NH:19][CH2:20][CH:21]=[O:22]>C(O)C.O>[Cl:16][CH2:17][CH2:18][N:19]([CH2:20][CH:21]=[O:22])[C:8]([NH:7][C:5]1[S:6][C:2]([Br:1])=[CH:3][N:4]=1)=[O:9]

참가 물질

5

반응물 3

HCID 241BenzeneHCID 230622645-Bromothiazol-2-yl IsocyanateHCID 543320492-beta-Chloroethylaminoacetaldehyde

생성물 1

HCID 541852552-[1-beta-Chloroethyl-3-(5-bromothiazol-2-yl)ureido]acetaldehyde

시약·촉매·용매 1

HCID 19096565Water ethanol용매

실험 절차

5-Bromothiazol-2-yl isocyanate dimer (17.0 grams), benzene (70 ml) and the dimethyl acetal of 2-β-chloroethylaminoacetaldehyde (13.5 grams) are charged into a glass reaction vessel equipped with a mechanical stirrer and thermometer. The reaction mixture is then stirred at room temperature for a period of about one hour. After this time the reaction mixture is filtered, and the filtrate is stripped of solvent under reduced pressure, leaving an oil. This oil is dissolved in an ethanol-water mixture, and the solution is filtered. The filtrate is then stripped of solvents under vacuum to yield the desired product the dimethyl acetal of 2-[1-β-chloroethyl-3-(5-bromothiazol-2-yl)ureido]acetaldehyde.

후처리

  1. customequipped with a mechanical stirrer
  2. filtrationAfter this time the reaction mixture is filtered
  3. customleaving an oil
  4. filtrationthe solution is filtered

출처 및 근거

ORD 기록
ord-84f07e699b154ed68faa9392adbdb45b
출처 데이터셋
uspto-grants-1978_04
특허 번호
US04086240

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