HCID 178479460, 화합물 → HCID 178479458, 화합물

HRID 2083832노트

반응식

HRID 2083832 반응식
[ClH:1].C(OC([NH:12][C@H:13]([C:21]([N:23]1[CH2:34][CH2:33][CH2:32][C@H:24]1[C:25]([NH:27][CH2:28][C:29]([NH2:31])=[O:30])=[O:26])=[O:22])[CH2:14][CH2:15][CH2:16][NH:17][C:18](=[NH:20])[NH2:19])=O)C1C=CC=CC=1>CO>[ClH:1].[NH2:12][C@H:13]([C:21]([N:23]1[CH2:34][CH2:33][CH2:32][C@H:24]1[C:25]([NH:27][CH2:28][C:29]([NH2:31])=[O:30])=[O:26])=[O:22])[CH2:14][CH2:15][CH2:16][NH:17][C:18](=[NH:19])[NH2:20]

참가 물질

3

반응물 1

HCID 178479460HCID 178479460, 화합물

생성물 1

HCID 178479458HCID 178479458, 화합물

시약·촉매·용매 1

HCID 887Methanol용매

실험 절차

Nα -Benzyloxycarbonyl-L-arginyl-L-prolyl-glycinamide hydrochloride, (Example 1, part m) 1.2 g., is dissolved in 60 ml. of absolute methanol, treated with 380 mg. of 10% palladium-on-carbon and the flask flushed with nitrogen, then with hydrogen and the reduction carried out for 40 minutes. Completion of the reaction is determined by thin layer chromatography. The mixture is filtered to separate the catalyst and the filtrate is evaporated and dried under reduced pressure to yield L-arginyl-L-prolyl-glycinamide hydrochloride.

후처리

  1. dissolution, is dissolved in 60 ml
  2. customof 10% palladium-on-carbon and the flask flushed with nitrogen
  3. filtrationThe mixture is filtered
  4. customto separate the catalyst
  5. customthe filtrate is evaporated
  6. customdried under reduced pressure

출처 및 근거

ORD 기록
ord-80f43f592b9f42b69472853689d5419c
출처 데이터셋
uspto-grants-1978_04
특허 번호
US04086219

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