Isopropanol → HCID 22731978, 화합물
반응식
[OH-].[K+].[Cl:3][C:4]1[CH:5]=[C:6]2[C:11](=[CH:12][CH:13]=1)[S:10][CH2:9][CH2:8][C:7]2([C:15](N)=[O:16])[OH:14].C([OH:21])(C)C>O>[Cl:3][C:4]1[CH:5]=[C:6]2[C:11](=[CH:12][CH:13]=1)[S:10][CH2:9][CH2:8][C:7]2([C:15]([OH:16])=[O:21])[OH:14]참가 물질
5
실험 절차
Potassium hydroxide (5.1 g, 91 mmol) and 6-chloro-4-hydroxythiochromane-4-yl-carboxamide (1.36 g, 5.58 mmol; from step (ii) above) were dissolved in water (25 mL) and isopropanol and refluxed for 2 d. The isopropanol was removed under reduced pressure and the aqueous residue was washed with diethyl ether. Acidification with aq. HCl, extraction with ethyl acetate, and then drying and concentration in vacuo afforded the sub-title compound. Yield: 0.87 g (64%).
후처리
- customThe isopropanol was removed under reduced pressure
- washthe aqueous residue was washed with diethyl ether
- extractionAcidification with aq. HCl, extraction with ethyl acetate
- customdrying
- concentrationconcentration in vacuo
출처 및 근거
- ORD 기록
- ord-3d5ad0d1e80046b98e079ee8d5506cee
- 출처 데이터셋
- uspto-grants-2004_04
- 특허 번호
- US06716834B2
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