3-Methoxyaniline → HCID 22732351, 화합물

반응식

Cl[C:2]1[CH:7]=[C:6]([CH2:8][O:9][CH3:10])[N:5]=[C:4]([C:11]2[CH:16]=[CH:15][CH:14]=[C:13]([CH3:17])[CH:12]=2)[N:3]=1.[CH3:18][O:19][C:20]1[CH:25]=[CH:24][CH:23]=[C:22]([NH2:26])[CH:21]=1>>[CH3:18][O:19][C:20]1[CH:21]=[C:22]([CH:23]=[CH:24][CH:25]=1)[NH:26][C:2]1[CH:7]=[C:6]([CH2:8][O:9][CH3:10])[N:5]=[C:4]([C:11]2[CH:16]=[CH:15][CH:14]=[C:13]([CH3:17])[CH:12]=2)[N:3]=1

참가 물질

반응물 2

HCID 108243-Methoxyaniline

HCID 27953164-chloro-6-(methoxymethyl)-2-(3-methylphenyl)pyrimidine

생성물 1

HCID 22732351HCID 22732351, 화합물

실험 절차

The title compound was prepared from 4-chloro-6-(methoxymethyl)-2-(3-methylphenyl)pyrimidine (100 mg, 0.402 mmol) and m-anisidine (45 μl, 0.402 mmol) similar to Example 13 and isolated as a tan solid (154 mg). 1H NMR (CDCl3): 8.23 (d, J=9.0 Hz, 2H), 7.34 (s, 1H), 7.25-7.16 (m, 4H), 6.92-6.89 (m, 1H), 6.75 (s, 1H), 6.69-6.65 (m, 1H), 4.51 (s, 2H), 3.78 (s, 3H), 3.47 (s, 3H), 2.40 (s, 3H).

출처 및 근거

ORD 기록: ord-ac9678e2c26446e794b93233549f9328
출처 데이터셋: uspto-grants-2004_04
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US06716851B2

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