5,8-Difluoro-2H-chromene → 8-Bromo-5-fluoro-2H-chromene

반응식

FC1C=CC(F)=C2C=1C=CCO2.[Br:13][C:14]1[CH:19]=[CH:18][C:17]([F:20])=[CH:16][C:15]=1[O:21][CH2:22][C:23]#[CH:24]>>[Br:13][C:14]1[CH:19]=[CH:18][C:17]([F:20])=[C:16]2[C:15]=1[O:21][CH2:22][CH:23]=[CH:24]2

참가 물질

반응물 2

HCID 224828145,8-Difluoro-2H-chromene

HCID 224828471-Bromo-4-fluoro-2-[(prop-2-yn-1-yl)oxy]benzene

생성물 1

HCID 224828108-Bromo-5-fluoro-2H-chromene

실험 절차

This compound was prepared analogously to 5,8-difluoro-2H-chromene but using (15 g, 65 mmol) of 1-bromo-4-fluoro-2-prop-2-ynyloxybenzene to give the title compound (3.7 g, 25

출처 및 근거

ORD 기록: ord-5591c48c5ef94875b8842477b688c233
출처 데이터셋: uspto-grants-2004_04
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US06716850B2

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