2-(1-{3-[3-(benzyloxy)phenyl]propyl)-1H-imidazol-2-yl)-1-ethanol → 3-{3-[2-(2-hydroxyethyl)-1H-imidazol-1-yl]propyl}phenol

HRID 2084383노트

반응식

HRID 2084383 반응식
C([O:8][C:9]1[CH:10]=[C:11]([CH2:15][CH2:16][CH2:17][N:18]2[CH:22]=[CH:21][N:20]=[C:19]2[CH2:23][CH2:24][OH:25])[CH:12]=[CH:13][CH:14]=1)C1C=CC=CC=1>[C].[Pd]>[OH:25][CH2:24][CH2:23][C:19]1[N:18]([CH2:17][CH2:16][CH2:15][C:11]2[CH:10]=[C:9]([OH:8])[CH:14]=[CH:13][CH:12]=2)[CH:22]=[CH:21][N:20]=1

참가 물질

3

반응물 1

HCID 227333732-(1-{3-[3-(benzyloxy)phenyl]propyl)-1H-imidazol-2-yl)-1-ethanol

생성물 1

HCID 227333553-{3-[2-(2-hydroxyethyl)-1H-imidazol-1-yl]propyl}phenol수율 95.4%

시약·촉매·용매 1

HCID 178418390HCID 178418390, 화합물촉매

실험 절차

Using 2-(1-{3-[3-(benzyloxy)phenyl]propyl)-1H-imidazol-2-yl)-1-ethanol (2.42 g) and 10% palladium carbon (0.24 g), the same reaction as Reference Example 11-(v) was carried out to yield the titled compound (1.69 g) as colorless crystals.

후처리

  1. customthe same reaction as Reference Example 11-(v)

출처 및 근거

ORD 기록
ord-efc05f0e23214bf391183e3a876b8e22
출처 데이터셋
uspto-grants-2004_04
특허 번호
US06716863B2

반응 노트

불러오는 중…