Benzeneacetic acid, 2-fluoro- → HCID 10728612, 화합물

반응식

[F:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[CH2:8][C:9]([OH:11])=O.C(N1C=CN=C1)(N1C=CN=C1)=O.[K+].[CH3:25][CH:26](C([O-])=O)[C:27]([O:29][CH2:30][CH3:31])=[O:28].[Cl-].[Mg+2].[Cl-]>>[F:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[CH2:8][C:9](=[O:11])[CH:26]([CH3:25])[C:27]([O:29][CH2:30][CH3:31])=[O:28]

참가 물질

반응물 4

HCID 67979Benzeneacetic acid, 2-fluoro-

HCID 682631,1'-Carbonyldiimidazole

HCID 5360315Magnesium Chloride

HCID 23679020HCID 23679020, 화합물

생성물 1

HCID 10728612HCID 10728612, 화합물

실험 절차

That is, 2-fluorophenylacetic acid (4) and 1,1′-carbonyldiimidazole (CDI) are reacted, followed by treatment with ethyl methylmalonate mono potassium salt in the presence of magnesium chloride to obtain ethyl 4-(2-fluorophenyl)-2-methyl-3-oxobutyrate (5).

출처 및 근거

ORD 기록: ord-fc00ac4136334554abc7861439ebf569
출처 데이터셋: uspto-grants-2004_04
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US06717016B2

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