HCID 10728612, 화합물 → HCID 12070572, 화합물

반응식

[F:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[CH2:8][C:9](=[O:17])[CH:10]([CH3:16])[C:11]([O:13][CH2:14][CH3:15])=[O:12].C1OC2C(C3C4OCOC=4C=CC=3P(C3C=CC=CC=3)C3C=CC=CC=3)=C(P(C3C=CC=CC=3)C3C=CC=CC=3)C=CC=2O1>>[F:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[CH2:8][CH:9]([OH:17])[CH:10]([CH3:16])[C:11]([O:13][CH2:14][CH3:15])=[O:12]

참가 물질

반응물 2

HCID 10728612HCID 10728612, 화합물

HCID 110175104,4'-Bi-1,3-benzodioxole-5,5'-diylbis(diphenylphosphine)

생성물 1

HCID 12070572HCID 12070572, 화합물

실험 절차

The thus obtained compound (5) is asymmetrically hydrogenated using ((R)—SEGPHOS™)-Ru complex to obtain optically active ethyl 4-(2-fluorophenyl)-3-hydroxy-2-methylbutyrate (6) as a mixture of diastereomers.

출처 및 근거

ORD 기록: ord-084af2cc9280444c8e18d6d8f3470fc4
출처 데이터셋: uspto-grants-2004_04
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US06717016B2

반응 노트

불러오는 중…