Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
p-Toluenesulfonic acid → 7-Methoxy-spiro[1,3-benzodioxole-2,1'-cyclopentane]
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | p-Toluenesulfonic acid | HCID 6101 | — |
| 반응물 | Cyclopentanone | HCID 8452 | — |
| 반응물 | 3-Methoxycatechol | HCID 13622 | — |
| 반응물 | Sodium Hydroxide | HCID 14798 | — |
| 반응물 | Methylorthoformate | HCID 53629101 | — |
| 용매 | Benzene | HCID 241 | — |
| 생성물 | 7-Methoxy-spiro[1,3-benzodioxole-2,1'-cyclopentane] | HCID 22734358 | — |
반응 단계
A mixture of 3-methoxycatechol (22.6 g), cyclopentanone (27.1 g), methyl orthoformate (34.2 g), p-toluenesulfonic acid.monohydrate (0.2 g), and benzene (300 ml) was heated under reflux for 24 hours. After being allowed to stand for cooling, a dilute solution of sodium hydroxide was added to the mixture followed by extraction with ether. The organic layer was washed with a saturated saline and dried over anhydrous potassium carbonate. The solvent was distilled off under reduced pressure to give Compound IIax-a (30 g, 90%) as a colorless oily substance.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US06716987B1 |
| 출처 데이터셋 | uspto-grants-2004_04 |
| ORD ID | ord-5538919769214dd8ac3ff1eea426cd8d |
| 출처 메모 | uspto-grants-2004_04 |