Trifluoroacetic acid → N-[(5S)-3,9,10,11-Tetramethoxy-6,7-dihydro-5H-dibenzo[a,c]cyclohepten-5-yl]-2-[2-aminoacetylamino]acetamide

HRID 2085023노트

반응식

HRID 2085023 반응식
[CH3:1][O:2][C:3]1[CH:4]=[CH:5][C:6]2[C:12]3[C:13]([O:21][CH3:22])=[C:14]([O:19][CH3:20])[C:15]([O:17][CH3:18])=[CH:16][C:11]=3[CH2:10][CH2:9][C@H:8]([NH:23][C:24](=[O:38])[CH2:25][NH:26][C:27](=[O:37])[CH2:28][NH:29]C(OCCCC)=O)[C:7]=2[CH:39]=1.C(O)(C(F)(F)F)=O>ClCCl>[CH3:1][O:2][C:3]1[CH:4]=[CH:5][C:6]2[C:12]3[C:13]([O:21][CH3:22])=[C:14]([O:19][CH3:20])[C:15]([O:17][CH3:18])=[CH:16][C:11]=3[CH2:10][CH2:9][C@H:8]([NH:23][C:24](=[O:38])[CH2:25][NH:26][C:27](=[O:37])[CH2:28][NH2:29])[C:7]=2[CH:39]=1

참가 물질

4

반응물 2

HCID 6422Trifluoroacetic acidHCID 69732781N-[(5S)-3,9,10,11-tetramethoxy-6,7-dihydro-5H-dibenzo [a,c]cyclohepten-5-yl]-2-[2-(butoxycarbonylamino)acetylamino]acetamide

생성물 1

HCID 9889617N-[(5S)-3,9,10,11-Tetramethoxy-6,7-dihydro-5H-dibenzo[a,c]cyclohepten-5-yl]-2-[2-aminoacetylamino]acetamide수율 65%

시약·촉매·용매 1

HCID 6344Dichloromethane용매

실험 절차

A solution of N-[(5S)-3,9,10,11-tetramethoxy-6,7-dihydro-5H-dibenzo[a,c]cyclohepten-5-yl]-2-[2-(butoxycarbonylamino)acetylamino]acetamide (0.9 g; 0.64 mmol) in dichloromethane (6 ml) was treated with TFA (6 ml) at ambient temperature for 0.5 hour. After evaporation to dryness, the residue was neutralised to pH 6.5 with solid sodium hydrogen carbonate and purified on reverse phase silica eluting with a gradient of 30-40% methanol/ammonium carbonate buffer (2 g/1, pH 7). The appropriate fractions were evaporated to dryness and triturated in ether to give the title compound.

후처리

  1. customAfter evaporation to dryness
  2. custompurified on reverse phase silica eluting with a gradient of 30-40% methanol/ammonium carbonate buffer (2 g/1, pH 7)
  3. customThe appropriate fractions were evaporated to dryness
  4. customtriturated in ether

출처 및 근거

ORD 기록
ord-b2a99282a9e041adafd6528a09e969bb
출처 데이터셋
uspto-grants-2004_04
특허 번호
US06720323B2

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