Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
3,3-Dimethylbutanal → 2-Benzyloxycarbonylamino-5,5-dimethyl-hex-2-enoic acid methyl ester
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | 3,3-Dimethylbutanal | HCID 76335 | — |
| 반응물 | 1,8-Diazabicyclo(5.4.0)undec-7-ene | HCID 81184 | — |
| 반응물 | Methyl 2-{[(benzyloxy)carbonyl]amino}-2-(dimethyl phosphono)acetate | HCID 2734718 | — |
| 용매 | Dichloromethane | HCID 6344 | — |
| 용매 | Tetrahydrofuran | HCID 8028 | — |
| 생성물 | 2-Benzyloxycarbonylamino-5,5-dimethyl-hex-2-enoic acid methyl ester | HCID 69433708 | 94.4% |
반응 단계
N-(Benzyloxycarbonyl)-α-phosphonoglycine trimethyl ester (2 g, 6.0 mmol, 1.0 equiv) was dissolved in dry THF (20 mL). tert-Butylacetaldehyde (0.758 mL, 6.0 mmol, 1.0 equiv) and DBU (0.903 mL, 6.0 mmol, 1.0 equiv) were added and the reaction mixture was stirred for 16 h. The solution was diluted with 100 mL of CH2Cl2 and washed with 1×50 mL water, and 1×50 mL brine. The organic layer was dried over Na2SO4, decanted and concentrated in vacuo to provide 2-benzyloxycarbonylamino-5,5-dimethyl-hex-2-enoic acid methyl ester as a thick oil (1.73 g, 94%) which was used without further purification; MS: 306 (M+1).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US06720319B2 |
| 출처 데이터셋 | uspto-grants-2004_04 |
| ORD ID | ord-a0210c10c5bc4098bf37eed1d5f49f65 |
| 출처 메모 | uspto-grants-2004_04 |