참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | Ethyl Acetate | HCID 8857 | — |
| 반응물 | 2-(3-Methoxyphenyl)-1-phenylethan-1-one | HCID 2759614 | — |
| 반응물 | Lithium bis(trimethylsilyl)amide | HCID 57426343 | — |
| 용매 | Tetrahydrofuran | HCID 8028 | — |
| 생성물 | Ethyl 4-(m-methoxyphenyl)-3-phenyl-3-hydroxybutyrate | HCID 22602685 | 86% |
반응 단계
Lithium hexamethyidisilazane (88.5 mL, 88.5 mmol) was added to THF (150 mL) at −78° C. After 15 minutes, ethyl acetate (7.79 g, 88.5 mmol) was added over 10 minutes and stirred at −78° C. for 30 minutes. The m-methoxybenzyl phenyl ketone in (10.0 g, 44.25 mmol) THF (100 mL) was added over 15 minutes and kept at that temperature for 3 hours. The reaction mixture was quenched at that temperature with saturated ammonium chloride (15 mL). The reaction mixture was diluted with ether (200 mL) and the organic layer was washed with brine, (100 mL), dried and concentrated to afford the desired product (12 g, 86% yield). NMR was consistent with the desired structure.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 특허 번호 | US06720315B2 |
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| 출처 데이터셋 | uspto-grants-2004_04 |
|---|
| ORD ID | ord-0d7cb346805c40b583610cf6d62715e4 |
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| 출처 메모 | uspto-grants-2004_04 |
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