(S)-(+)-Glycidyl-4-nitrobenzoate → (s)-3-(7-Glycidyloxybenzo(b)furan-2-yl)-5-methyl-1,2,4-oxadiazole

반응식

[OH:1][C:2]1[C:7]2[O:8][C:9]([C:11]3[N:15]=[C:14]([CH3:16])[O:13][N:12]=3)=[CH:10][C:6]=2[CH:5]=[CH:4][CH:3]=1.S(C1C=CC([N+]([O-])=O)=CC=1)(O[CH2:21][C@H:22]1[O:24][CH2:23]1)(=O)=O>>[CH2:21]([O:1][C:2]1[C:7]2[O:8][C:9]([C:11]3[N:15]=[C:14]([CH3:16])[O:13][N:12]=3)=[CH:10][C:6]=2[CH:5]=[CH:4][CH:3]=1)[C@H:22]1[O:24][CH2:23]1

참가 물질

반응물 2

HCID 10868995(S)-(+)-Glycidyl-4-nitrobenzoate

HCID 227290843-(7-Hydroxybenzo(b)furan-2-yl)-5-methyl-1,2,4-oxadiazole

생성물 1

HCID 60078028(s)-3-(7-Glycidyloxybenzo(b)furan-2-yl)-5-methyl-1,2,4-oxadiazole수율 90%

실험 절차

By the reactions in the same manner as in Starting Material Synthesis Example 1 using 3-(7-hydroxybenzo(b)furan-2-yl)-5-methyl-1,2,4-oxadiazole (1.5 g) and (S)-glycidyl nosylate (1.8 g), the title compound (1.7 g) was obtained as white crystals.

출처 및 근거

ORD 기록: ord-58383f3288c644b3b50ca9e2ee80b294
출처 데이터셋: uspto-grants-2004_04
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US06720320B2

반응 노트

불러오는 중…