참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | 1,2-Phenylenediamine dihydrochloride | HCID 11990 | — |
| 반응물 | Sodium Hydroxide | HCID 14798 | — |
| 반응물 | Cyclopropanecarboxylic acid | HCID 15655 | — |
| 용매 | Water | HCID 962 | — |
| 생성물 | 2-cyclopropyl-1H-1,3-benzodiazole | HCID 1084419 | 13% |
반응 단계
2-cyclopropanecarboxylic acid (4 g, 52 mmol) was treated with phenylenediamine bis-hydrochloride (1 eq) and polyphosphosphoric acid (52 mL) and heated to 160° C. for 6 h. The reaction was cooled to 0° C. and diluted with water, then basified with NaOH (50% aqueous) until pH>10. The solution was extracted with ethyl acetate, dried (MgSO4), filtered and concentrated, purified by flash chromatography (100% ethyl acetate) giving 2-cyclopropylbenzimidazole (1.1 g, 13%). MS found: (M+H)+=159.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 특허 번호 | US06720329B2 |
|---|
| 출처 데이터셋 | uspto-grants-2004_04 |
|---|
| ORD ID | ord-6ebfa19a6cfc4642af8e40307979b7b3 |
|---|
| 출처 메모 | uspto-grants-2004_04 |
|---|
