1,3-Propanediol → 4-(1,3,2-Dioxaborinan-2-yl)benzoic acid

HRID 2085743노트

반응식

HRID 2085743 반응식
[OH:1][B:2]([OH:12])[C:3]1[CH:11]=[CH:10][C:6]([C:7]([OH:9])=[O:8])=[CH:5][CH:4]=1.[CH2:13](O)[CH2:14][CH2:15]O>C1(C)C=CC=CC=1>[O:1]1[CH2:15][CH2:14][CH2:13][O:12][B:2]1[C:3]1[CH:11]=[CH:10][C:6]([C:7]([OH:9])=[O:8])=[CH:5][CH:4]=1

참가 물질

4

반응물 2

HCID 104421,3-PropanediolHCID 3121834-Carboxyphenylboronic Acid

생성물 1

HCID 145278654-(1,3,2-Dioxaborinan-2-yl)benzoic acid

시약·촉매·용매 1

HCID 1140Toluene용매

실험 절차

A mixture of 4-(dihydroxyboryl)benzoic acid (30.00 g, 181 mmol) and 1,3-propanediol (15.20 g, 200 mmol) in toluene (750 mL) at 140° C. was stirred for 6 hours while collecting the water removed by azeotrope formation. The mixture was concentrated to provide the desired product.

후처리

  1. customwhile collecting the water
  2. customremoved by azeotrope formation
  3. concentrationThe mixture was concentrated

출처 및 근거

ORD 기록
ord-1c9f953facd94e219498da73566bf0e1
출처 데이터셋
uspto-grants-2004_04
특허 번호
US06720338B2

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