Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Hydrochloric Acid → 5-Chlorobenzo[b]thiophene-3-methanol
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Hydrochloric Acid | HCID 313 | — |
| 반응물 | Potassium Acetate | HCID 517044 | — |
| 반응물 | 3-(Bromomethyl)-5-chloro-1-benzothiophene | HCID 2779857 | — |
| 용매 | Sodium Hydroxide | HCID 14798 | — |
| 용매 | 1,4-Dioxane | HCID 31275 | — |
| 생성물 | 5-Chlorobenzo[b]thiophene-3-methanol | HCID 2776136 | — |
반응 단계
A solution of 3-bromomethyl-5-chlorobenzothiophene (2.5 g, 9.56 mmol) and potassium acetate (1.96 g, 20 mmol) in 1M NaOH (40 mL) and dioxane (40 mL) was heated to reflux for 24 hours, adjusted to pH<7 with 1M HCl, and extracted with ethyl acetate (3×). The combined extracts were washed with brine, concentrated, and purified by flash column chromatography on silica gel with 50% ethyl acetate/hexanes to provide the desired product.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US06720338B2 |
| 출처 데이터셋 | uspto-grants-2004_04 |
| ORD ID | ord-92e00df66e1640feab302bb6da8b03a9 |
| 출처 메모 | uspto-grants-2004_04 |