Sodium Methoxide → 4-Chloro-2-methoxymethylpyridine

HRID 2086257노트

반응식

HRID 2086257 반응식
Cl.[Cl:2][C:3]1[CH:8]=[CH:7][N:6]=[C:5]([CH2:9]Cl)[CH:4]=1.[CH3:11][O-:12].[Na+]>CO>[Cl:2][C:3]1[CH:8]=[CH:7][N:6]=[C:5]([CH2:9][O:12][CH3:11])[CH:4]=1

참가 물질

4

반응물 2

HCID 10942334Sodium MethoxideHCID 227272744-Chloro-2-(chloromethyl)pyridine--hydrogen chloride (1/1)

생성물 1

HCID 227270924-Chloro-2-methoxymethylpyridine수율 82%

시약·촉매·용매 1

HCID 887Methanol용매

반응 조건

온도
70 °C

실험 절차

A mixture of 4-chloro-2-chloromethylpyridine hydrochloride (0.43 g), sodium methoxide (1.11 g) and methanol (15 ml) was stirred at room temperature for 10 hours and at 70° C. for 7 hours. The reaction mixture was concentrated, and the residue was combined with water and methylene chloride, and the organic phase was separated. After washing with saturated aqueous sodium bicarbonate followed by drying and concentrating, a title compound (0.28 g) was obtained as a tan oil.

후처리

  1. concentrationThe reaction mixture was concentrated
  2. customthe organic phase was separated
  3. washAfter washing with saturated aqueous sodium bicarbonate
  4. customby drying
  5. concentrationconcentrating

출처 및 근거

ORD 기록
ord-01b252892f29416aba673e6e2f47436c
출처 데이터셋
uspto-grants-2004_04
특허 번호
US06723722B1

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