Furan-3-boronic acid → HCID 22316983, 화합물

반응식

Br[C:2]1[CH:7]=[CH:6][C:5]([N:8]2[C:12]([C:13]3[CH:18]=[CH:17][C:16]([S:19]([CH3:22])(=[O:21])=[O:20])=[CH:15][CH:14]=3)=[CH:11][CH:10]=[C:9]2[CH3:23])=[CH:4][CH:3]=1.[O:24]1[CH:28]=[CH:27][C:26](B(O)O)=[CH:25]1>>[CH3:22][S:19]([C:16]1[CH:17]=[CH:18][C:13]([C:12]2[N:8]([C:5]3[CH:6]=[CH:7][C:2]([C:26]4[CH:27]=[CH:28][O:24][CH:25]=4)=[CH:3][CH:4]=3)[C:9]([CH3:23])=[CH:10][CH:11]=2)=[CH:14][CH:15]=1)(=[O:21])=[O:20]

참가 물질

반응물 2

HCID 2734358Furan-3-boronic acid

HCID 223168431-(4-Bromophenyl)-2-methyl-5-[4-(methylsulfonyl)phenyl]-1H-pyrrole

생성물 1

HCID 22316983HCID 22316983, 화합물

실험 절차

The title compound was prepared according to the procedure of Example 35 using 1-(4-bromophenyl)-2-methyl-5-[4-(methylsulfonyl)phenyl]-1H-pyrrole instead of 1-(4-bromophenyl)-2-[3-fluoro-4-(methylsulfonyl)phenyl]-5-methyl-1H-pyrrole and 3-furanboronic acid instead of 2-furanboronic acid in step 4.

출처 및 근거

ORD 기록: ord-e4574d79685e45cc9644ab0756423439
출처 데이터셋: uspto-grants-2004_04
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US06727238B2

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