Phenacyl bromide → N~1~-(4-Phenyl-1,3-thiazol-2-yl)benzene-1,3-diamine

HRID 2086775노트

반응식

HRID 2086775 반응식
C([NH:4][C:5]1[CH:6]=[C:7]([NH:11][C:12]([NH2:14])=[S:13])[CH:8]=[CH:9][CH:10]=1)(=O)C.Br[CH2:16][C:17]([C:19]1[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=1)=O>C(O)C>[C:19]1([C:17]2[N:14]=[C:12]([NH:11][C:7]3[CH:6]=[C:5]([CH:10]=[CH:9][CH:8]=3)[NH2:4])[S:13][CH:16]=2)[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=1

참가 물질

4

반응물 2

HCID 6259Phenacyl bromideHCID 6451295Acetamide, N-(3-((aminothioxomethyl)amino)phenyl)-

생성물 1

HCID 22724394N~1~-(4-Phenyl-1,3-thiazol-2-yl)benzene-1,3-diamine수율 82%

시약·촉매·용매 1

HCID 702Ethanol용매

실험 절차

A mixture of N-(3-acetylaminophenyl)thiourea (0.84 g) and 2-bromoacetophenone (0.84 g) in ethanol (10 ml) was refluxed for 15 minutes. After evaporation of the solvent, 3N hydrochloric acid was added thereto and the mixture was refluxed for 30 minutes. The mixture was made basic with sodium bicarbonate and extracted with ethyl acetate. The organic solution was washed with water and brine, dried over magnesium sulfate and concentrated. The residue was crystallized from ethanol to give 3-(4-phenylthiazol-2-yl)aminoaniline (0.88 g).

후처리

  1. temperaturewas refluxed for 15 minutes
  2. customAfter evaporation of the solvent, 3N hydrochloric acid
  3. additionwas added
  4. temperaturethe mixture was refluxed for 30 minutes
  5. extractionextracted with ethyl acetate
  6. washThe organic solution was washed with water and brine
  7. dry with materialdried over magnesium sulfate
  8. concentrationconcentrated
  9. customThe residue was crystallized from ethanol

출처 및 근거

ORD 기록
ord-6cd90584d27645e1bf2ef90a9cd72202
출처 데이터셋
uspto-grants-2004_04
특허 번호
US06727245B2

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