3-(2-Chloro-6-fluorophenyl)-5-methylisoxazole-4-carbonyl chloride → 3-{4-[3-(Isobutyrylamino)phenyl]-1-piperidinyl}propyl 3-(2-chloro-6-fluorophenyl)-5-methyl-4-isoxazolecarboxylate

HRID 2087440

반응식

HRID 2087440 반응식
[OH:1][CH2:2][CH2:3][CH2:4][N:5]1[CH2:10][CH2:9][CH:8]([C:11]2[CH:12]=[C:13]([NH:17][C:18](=[O:22])[CH:19]([CH3:21])[CH3:20])[CH:14]=[CH:15][CH:16]=2)[CH2:7][CH2:6]1.[Cl:23][C:24]1[CH:29]=[CH:28][CH:27]=[C:26]([F:30])[C:25]=1[C:31]1[C:35]([C:36](Cl)=[O:37])=[C:34]([CH3:39])[O:33][N:32]=1>>[Cl:23][C:24]1[CH:29]=[CH:28][CH:27]=[C:26]([F:30])[C:25]=1[C:31]1[C:35]([C:36]([O:1][CH2:2][CH2:3][CH2:4][N:5]2[CH2:10][CH2:9][CH:8]([C:11]3[CH:16]=[CH:15][CH:14]=[C:13]([NH:17][C:18](=[O:22])[CH:19]([CH3:20])[CH3:21])[CH:12]=3)[CH2:7][CH2:6]2)=[O:37])=[C:34]([CH3:39])[O:33][N:32]=1

참가 물질

3

반응물 2

HCID 27365813-(2-Chloro-6-fluorophenyl)-5-methylisoxazole-4-carbonyl chlorideHCID 22048877N-{3-[1-(3-Hydroxypropyl)-4-piperidinyl]phenyl}-2-methylpropanamide

생성물 1

HCID 220491243-{4-[3-(Isobutyrylamino)phenyl]-1-piperidinyl}propyl 3-(2-chloro-6-fluorophenyl)-5-methyl-4-isoxazolecarboxylate

실험 절차

Prepared by Procedure Q1 and Scheme C2 (TEA) using N-{3-[1-(3-hydroxypropyl)-4-piperidinyl]phenyl}-2-methylpropanamide and 3-(2-chloro-6-fluorophenyl)-5-methyl-4-isoxazolecarbonyl chloride: ESMS m/e: 542.2 (M+H)+.

후처리

  1. customPrepared by Procedure Q1 and Scheme C2 (TEA)

출처 및 근거

ORD 기록
ord-fab446b3722449ef9646fa988f040d71
출처 데이터셋
uspto-grants-2004_04
특허 번호
US06727264B1

연결된 노트

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