Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
3-(2-Chloro-6-fluorophenyl)-5-methylisoxazole-4-carbonyl chloride → 4-{4-[3-(Isobutyrylamino)phenyl]-1-piperidinyl)-1-phenylbutyl 3-(2-chloro-6-fluorophenyl)-5-methyl-4-isoxazolecarboxylate
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | 3-(2-Chloro-6-fluorophenyl)-5-methylisoxazole-4-carbonyl chloride | HCID 2736581 | — |
| 반응물 | N-(3-[1-(4-hydroxy-4-phenylbutyl)-4-piperidinyl]phenyl}-2-methylpropanamide | HCID 22048814 | — |
| 생성물 | 4-{4-[3-(Isobutyrylamino)phenyl]-1-piperidinyl)-1-phenylbutyl 3-(2-chloro-6-fluorophenyl)-5-methyl-4-isoxazolecarboxylate | HCID 20723013 | — |
반응 단계
Prepared by Procedure Q1 and Scheme C2 (TEA) using N-{3-[1-(4-hydroxy-4-phenylbutyl)-4-piperidinyl]phenyl}-2-methylpropanamide and 3-(2-chloro-6-fluorophenyl)-5-methyl-4-isoxazolecarbonyl chloride: Anal. Calcd for C36H39ClFN3O4+0.54CHCl3: C, 63.0; H, 5.72; N, 6.03. Found: C, 63.0; H, 5.54; N, 6.05; ESMS m/e: 632.2 (M+H)+.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US06727264B1 |
| 출처 데이터셋 | uspto-grants-2004_04 |
| ORD ID | ord-848db07cf2f64468969fb2bd9ac87c37 |
| 출처 메모 | uspto-grants-2004_04 |