2-methyl-N-[3-(4-piperidyl)phenyl]propanamide → 2-Methyl-N-(3-{1-[(2S)-2-methyl-3-(2,4,5-trifluorophenoxy)propyl]-4-piperidinyl}phenyl)propanamide
반응식
Cl[CH2:2][C@H:3]([CH3:15])[CH2:4][O:5][C:6]1[CH:11]=[C:10]([F:12])[C:9]([F:13])=[CH:8][C:7]=1[F:14].[CH3:16][CH:17]([CH3:33])[C:18]([NH:20][C:21]1[CH:26]=[CH:25][CH:24]=[C:23]([CH:27]2[CH2:32][CH2:31][NH:30][CH2:29][CH2:28]2)[CH:22]=1)=[O:19]>>[CH3:16][CH:17]([CH3:33])[C:18]([NH:20][C:21]1[CH:26]=[CH:25][CH:24]=[C:23]([CH:27]2[CH2:32][CH2:31][N:30]([CH2:2][C@H:3]([CH3:15])[CH2:4][O:5][C:6]3[CH:11]=[C:10]([F:12])[C:9]([F:13])=[CH:8][C:7]=3[F:14])[CH2:29][CH2:28]2)[CH:22]=1)=[O:19]참가 물질
3
실험 절차
Prepared by Procedure G and Scheme B1 using 1-{[(2R)-3-chloro-2-methylpropyl]oxy}-2,4,5-trifluorobenzene and 2-methyl-N-[3-(4-piperidinyl)phenyl]propanamide: ESMS m/e: 449.2 (M+H)+.
후처리
- customPrepared by Procedure G and Scheme B1