Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
HRID 20877생성일: 2026년 10월 23일
2-Bromopyrimidine → (S)-tert-Butyl 2-(5-(4'-(2-((S)-1-((S)-3-methyl-2-(pyrimidin-2-ylamino)butanoyl)pyrrolidin-2-yl)-1H-imidazol-5-yl)biphenyl-4-yl)-1H-imidazol-2-yl)pyrrolidine-1-carboxylate
https://huagongshe.com/ko/reaction/20877
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | 2-Bromopyrimidine | HCID 78345 | — |
| 반응물 | Diisopropylethylamine | HCID 81531 | — |
| 반응물 | (S)-tert-butyl 2-(5-(4'-(2-((S)-1-((s)-2-amino-3-methylbutanoyl)pyrrolidin-2-yl)-1H-imidazol-5-yl)biphenyl-4-yl)-1H-imidazol-2-yl)pyrrolidine-1-carboxylate | HCID 59166546 | — |
| 용매 | Dimethylsulfoxide toluene | HCID 22340214 | — |
| 생성물 | (S)-tert-Butyl 2-(5-(4'-(2-((S)-1-((S)-3-methyl-2-(pyrimidin-2-ylamino)butanoyl)pyrrolidin-2-yl)-1H-imidazol-5-yl)biphenyl-4-yl)-1H-imidazol-2-yl)pyrrolidine-1-carboxylate | HCID 59166544 | 110.8% |
반응 단계
A mixture of (S)-tert-butyl 2-(5-(4′-(2-((S)-1-((s)-2-amino-3-methylbutanoyl)pyrrolidin-2-yl)-1H-imidazol-5-yl)biphenyl-4-yl)-1H-imidazol-2-yl)pyrrolidine-1-carboxylate (cj-2) (0.45 g, 0.72 mmol), 2-bromopyrimidine (0.37 g, 2.34 mmol) and iPr2NEt (0.20 mL, 1.18 mmol) in toluene-DMSO (4:1, 5 mL) was heated at 90° C. overnight. The volatiles were removed in vacuo and the residue was purified by preparative HPLC (YMC Pack C-18, 30×100 mm/MeCN—H2O-TFA). The title compound (0.56 g, 74%), as its TFA salt, was obtained as a yellow-orange glass.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| 특허 번호 | US07745636B2 |
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| 출처 데이터셋 | uspto-grants-2010_06 |
|---|
| ORD ID | ord-b899a2047c3f4e4584d5fb3d3215fd66 |
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| 출처 메모 | uspto-grants-2010_06 |
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