Water → 1-{3-[5-(2-morpholin-4-ylethoxy)pyrimidin-2-yl]benzyl}-1H-benzotriazole

HRID 2088416노트

반응식

HRID 2088416 반응식
[NH:1]1[C:5]2[CH:6]=[CH:7][CH:8]=[CH:9][C:4]=2[N:3]=[N:2]1.Cl.Cl[CH2:12][C:13]1[CH:14]=[C:15]([C:19]2[N:24]=[CH:23][C:22]([O:25][CH2:26][CH2:27][N:28]3[CH2:33][CH2:32][O:31][CH2:30][CH2:29]3)=[CH:21][N:20]=2)[CH:16]=[CH:17][CH:18]=1.C(=O)([O-])O.[Na+].O>C(#N)C>[N:28]1([CH2:27][CH2:26][O:25][C:22]2[CH:23]=[N:24][C:19]([C:15]3[CH:14]=[C:13]([CH:18]=[CH:17][CH:16]=3)[CH2:12][N:1]3[C:5]4[CH:6]=[CH:7][CH:8]=[CH:9][C:4]=4[N:3]=[N:2]3)=[N:20][CH:21]=2)[CH2:29][CH2:30][O:31][CH2:32][CH2:33]1

참가 물질

6

반응물 4

HCID 962WaterHCID 516892Sodium BicarbonateHCID 669855014-{2-[2-(3-Chloromethylphenyl)pyrimidin-5-yloxy]ethyl}morpholine hydrochlorideHCID 178418385HCID 178418385, 화합물

생성물 1

HCID 461793741-{3-[5-(2-morpholin-4-ylethoxy)pyrimidin-2-yl]benzyl}-1H-benzotriazole

시약·촉매·용매 1

HCID 6342Acetonitrile용매

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온도
90 °C

실험 절차

49 mg (0.41 mmol) of 1H-benzotriazole, 150 mg (0.41 mmol) of 4-{2-[2-(3-chloromethylphenyl)pyrimidin-5-yloxy]ethyl}morpholine hydrochloride and 136 mg (1.62 mmol) of sodium hydrogencarbonate are suspended in 4 ml of acetonitrile and stirred at 90° C. for 18. Water is added to the reaction mixture, which is then extracted with ethyl acetate. The organic phase is dried over sodium sulfate, evaporated and purified by means of column chromatography on silica gel.

후처리

  1. extractionis then extracted with ethyl acetate
  2. dry with materialThe organic phase is dried over sodium sulfate
  3. customevaporated
  4. custompurified by means of column chromatography on silica gel

출처 및 근거

ORD 기록
ord-322349e51c6540eeab3b66a35f6ff41f
출처 데이터셋
uspto-grants-2013_05
특허 번호
US08435986B2

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