(3R)-(+)-3-(tert-Butoxycarbonylamino)pyrrolidine → 4-(piperazin-1-yl)-6,7,8,9-tetrahydro-5H-cyclohepta[d]pyrimidin-2-amine

HRID 2088719노트

반응식

HRID 2088719 반응식
CC1C=CC(S(O[C:12]2[C:13]3[CH2:23][CH2:22][CH2:21][CH2:20][C:19](C)(C)[C:14]=3[N:15]=[C:16]([NH2:18])[N:17]=2)(=O)=O)=CC=1.[NH:26]1[CH2:30]C[C@@H:28]([NH:31][C:32](=O)OC(C)(C)C)[CH2:27]1>>[N:26]1([C:12]2[C:13]3[CH2:23][CH2:22][CH2:21][CH2:20][CH2:19][C:14]=3[N:15]=[C:16]([NH2:18])[N:17]=2)[CH2:27][CH2:28][NH:31][CH2:32][CH2:30]1

참가 물질

3

반응물 2

HCID 1514397(3R)-(+)-3-(tert-Butoxycarbonylamino)pyrrolidineHCID 866348802-amino-9,9-dimethyl-6,7,8,9-tetrahydro-5H-cyclohepta[d]pyrimidin-4-yl 4-methylbenzenesulfonate

생성물 1

HCID 444668764-(piperazin-1-yl)-6,7,8,9-tetrahydro-5H-cyclohepta[d]pyrimidin-2-amine

실험 절차

The title compound was prepared according to the procedure of Example 1E, substituting the product from Example 13C for the product of Example 1D and substituting piperazine for (R)-tert-butyl pyrrolidin-3-ylcarbamate. 1H NMR (300 MHz, CD3OD) δ 3.38 (m, 4H), 3.21 (, 4H), 2.74 (m, 2H), 2.62 (m, 2H), 1.86 (m, 2H), 1.57-1.71 (m, 4H). MS (DCI+) m/z 248 (M+H)+.

출처 및 근거

ORD 기록
ord-e9ab965c010e4a63bce4160fd8eb07a5
출처 데이터셋
uspto-grants-2013_05
특허 번호
US08436005B2

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