Dimethylamine → n,n-dimethyl-1,2,3,4-tetrahydronaphthalen-2-amine

HRID 2088738노트

반응식

HRID 2088738 반응식
CO.CN(C)C[CH:6]1[CH2:15][CH2:14][C:13]2[C:8](=[CH:9][CH:10]=[CH:11][CH:12]=2)[CH2:7]1.[CH3:17][NH:18][CH3:19].C1C(=O)CC2C(=CC=CC=2)C1>O1CCCC1>[CH3:17][N:18]([CH3:19])[CH:6]1[CH2:15][CH2:14][C:13]2[C:8](=[CH:9][CH:10]=[CH:11][CH:12]=2)[CH2:7]1

참가 물질

6

반응물 4

HCID 674DimethylamineHCID 887MethanolHCID 682662-TetraloneHCID 21063044HCID 21063044, 화합물

생성물 1

HCID 242461n,n-dimethyl-1,2,3,4-tetrahydronaphthalen-2-amine

시약·촉매·용매 1

HCID 8028Tetrahydrofuran용매2회

실험 절차

46 ml of a methanol solution of 0.3 M sodium cyanoborohydride-1/2 zinc chloride and 6.9 mL of a tetrahydrofuran solution of 2 M dimethylamine were added to a tetrahydrofuran (10 mL) solution of 2.02 g of β-tetralone, and stirred for a day at room temperature. The reaction liquid was concentrated, and 1 N hydrochloric acid was added thereto. The acidic solution was washed with ethyl acetate, then made alkaline with aqueous 5 M sodium hydroxide solution, and extracted with ethyl acetate. This was washed with saturated saline water, dried with anhydrous magnesium sulfate, and the solvent was evaporated away to obtain 857 mg of the entitled compound as a colorless oily substance.

후처리

  1. customThe reaction liquid
  2. concentrationwas concentrated
  3. addition1 N hydrochloric acid was added
  4. washThe acidic solution was washed with ethyl acetate
  5. extractionextracted with ethyl acetate
  6. washThis was washed with saturated saline water
  7. dry with materialdried with anhydrous magnesium sulfate
  8. customthe solvent was evaporated away

출처 및 근거

ORD 기록
ord-6196f24260f544bb88b4ad4091c8b7d6
출처 데이터셋
uspto-grants-2013_05
특허 번호
US08436004B2

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