HCID 58289789, 화합물 → HCID 58290015, 화합물

HRID 2088755

반응식

HRID 2088755 반응식
[CH3:1][C:2]1([CH3:13])[C:11]2[C:6](=[CH:7][C:8]([NH2:12])=[CH:9][CH:10]=2)[CH2:5][NH:4][CH2:3]1.Cl[C:15]1[N:20]=[C:19]2[N:21]([CH3:35])[C:22](=[O:34])[N:23]([C:26]3[C:31]([Cl:32])=[CH:30][CH:29]=[CH:28][C:27]=3[Cl:33])[C:24](=[NH:25])[C:18]2=[CH:17][N:16]=1.ClC1N=C2NC(=O)N(C3C(Cl)=CC=CC=3Cl)C(=N)C2=CN=1>>[Cl:32][C:31]1[CH:30]=[CH:29][CH:28]=[C:27]([Cl:33])[C:26]=1[N:23]1[C:24](=[NH:25])[C:18]2[C:19](=[N:20][C:15]([NH:12][C:8]3[CH:7]=[C:6]4[C:11]([C:2]([CH3:13])([CH3:1])[CH2:3][NH:4][CH2:5]4)=[CH:10][CH:9]=3)=[N:16][CH:17]=2)[N:21]([CH3:35])[C:22]1=[O:34]

참가 물질

4

반응물 3

HCID 58289789HCID 58289789, 화합물HCID 590215334,4-Dimethyl-1,2,3,4-tetrahydroisoquinolin-7-amineHCID 178507161HCID 178507161, 화합물

생성물 1

HCID 58290015HCID 58290015, 화합물

실험 절차

160 mg of the entitled compound was obtained as a white solid according to the same method as in Example 2, for which, however, 4,4-dimethyl-1,2,3,4-tetrahydroisoquinolin-7-amine was used in place of 2,4,4-trimethyl-1,2,3,4-tetrahydroisoquinolin-7-amine in Example 2, and 7-chloro-3-(2,6-dichlorophenyl)-4-imino-1-methyl-3,4-dihydropyrimido[4,5-d]pyrimidin-2(1H)-one obtained in Production Example 7 was used in place of 7-chloro-3-(2,6-dichlorophenyl)-4-imino-3,4-dihydropyrimido[4,5-d]pyrimidin-2(1H)-one.

후처리

  1. customobtained in Production Example 7

출처 및 근거

ORD 기록
ord-83dd1bb58d8446878e24d4dbc2628533
출처 데이터셋
uspto-grants-2013_05
특허 번호
US08436004B2

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