HCID 18382547, 화합물 → HCID 58289939, 화합물

반응식

C[N:2]1[CH2:11][C:10](C)(C)C2[C:4](=[CH:5]C(N)=CC=2)[CH2:3]1.Cl[C:16]1[N:21]=[C:20]2[N:22]([CH3:36])[C:23](=[O:35])[N:24]([C:27]3[C:32]([Cl:33])=[CH:31][CH:30]=[CH:29][C:28]=3[Cl:34])[C:25](=[NH:26])[C:19]2=[CH:18][N:17]=1.ClC1N=C2NC(=O)[N:46]([C:49]3[C:54](Cl)=[CH:53][CH:52]=[CH:51][C:50]=3Cl)C(=N)C2=CN=1>>[Cl:33][C:32]1[CH:31]=[CH:30][CH:29]=[C:28]([Cl:34])[C:27]=1[N:24]1[C:25](=[NH:26])[C:19]2[C:20](=[N:21][C:16]([NH:46][C:49]3[CH:50]=[C:51]4[C:52](=[CH:53][CH:54]=3)[CH:3]([CH2:4][CH3:5])[NH:2][CH2:11][CH2:10]4)=[N:17][CH:18]=2)[N:22]([CH3:36])[C:23]1=[O:35]

참가 물질

반응물 3

HCID 18382547HCID 18382547, 화합물

HCID 582897897-chloro-3-(2,6-dichlorophenyl)-4-imino-1-methyl-3,4-dihydropyrimido[4,5-d]pyrimidin-2(1H)-one

HCID 178507161HCID 178507161, 화합물

생성물 1

HCID 58289939HCID 58289939, 화합물

실험 절차

14 mg of 3-(2,6-dichlorophenyl)-7-(3′,4′-dihydro-2′H-spiro[cyclopropane-1,1′-isoquinolin]-6′-ylamino)-4-imino-1-methyl-3,4-dihydropyrimido[4,5-d]pyrimidin-2(1H)-one was obtained as a white solid according to the same method as in Example 2, for which, however, tert-butyl 6′-amino-3′,4′-dihydro-2′H-spiro[cyclopropane-1,1′-isoquinoline]-2′-carboxylate obtained in the reaction of Production Example 19-5) was used in place of 2,4,4-trimethyl-1,2,3,4-tetrahydroisoquinolin-7-amine in Example 2, and 7-chloro-3-(2,6-dichlorophenyl)-4-imino-1-methyl-3,4-dihydropyrimido[4,5-d]pyrimidin-2(1H)-one obtained in Production Example 7 was used in place of 7-chloro-3-(2,6-dichlorophenyl)-4-imino-3,4-dihydropyrimido[4,5-d]pyrimidin-2(1H)-one. In addition, as a by-product, 30 mg of 3-(2,6-dichlorophenyl)-7-[(1-ethyl-1,2,3,4-tetrahydroisoquinolin-6-yl)amino]-4-imino-1-methyl-3,4-dihydropyrimido[4,5-d]pyrimidin-2(1H)-one was obtained as a white solid. 3-(2,6-Dichlorophenyl)-7-(3′,4′-dihydro-2′H-spiro[cyclopropane-1,1′-isoquinolin]-6′-ylamino)-4-imino-1-methyl-3,4-dihydropyrimido[4,5-d]pyrimidin-2(1H)-one: