Ammonium Hydroxide → HCID 178451805, 화합물

HRID 2088878노트

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F[C:2](F)(F)[C:3]1[N:4]=[C:5]([CH:8]2[CH2:13][CH2:12][N:11]([C:14]([O:16][C:17]([CH3:20])([CH3:19])[CH3:18])=[O:15])[CH2:10][CH2:9]2)[NH:6][CH:7]=1.[OH-].[NH4+:24]>>[C:2]([C:3]1[N:4]=[C:5]([CH:8]2[CH2:13][CH2:12][N:11]([C:14]([O:16][C:17]([CH3:20])([CH3:19])[CH3:18])=[O:15])[CH2:10][CH2:9]2)[NH:6][CH:7]=1)#[N:24]

참가 물질

반응물 2

HCID 14923Ammonium Hydroxide

HCID 178451801HCID 178451801, 화합물

생성물 1

HCID 178451805HCID 178451805, 화합물수율 83%

반응 조건

온도: 60 °C

실험 절차

Combine tert-butyl 4-(4-(trifluoromethyl)-1H-imidazol-2-yl)piperidine-1-carboxylate (1.50 g, 4.70 mmol) and ammonium hydroxide (90 mL). Heat the reaction mixture at 60° C. for two days. Let cool to room temperature, then filter via Buchner funnel Wash the solids with water and hexanes to give the title compound as a white solid (1.08 g, 83%). MS (ES) m/z=221 [M]+.

후처리

temperatureLet cool to room temperature
filtrationfilter via Buchner funnel
washWash the solids with water and hexanes

출처 및 근거

ORD 기록: ord-263c2ef5117d40e995b2323055fc0ffc
출처 데이터셋: uspto-grants-2013_05
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US08436002B2

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