Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
HRID 2088998생성일: 2026년 10월 26일
Sodium Carbonate → 3-(2,6-dichloropyridin-4-yl)-1-(phenylsulfonyl)-1H-pyrrolo[2,3-b]pyridine
https://huagongshe.com/reaction/2088998
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | Sodium Carbonate | HCID 10340 | — |
| 반응물 | 2,6-Dichloro-4-iodopyridine | HCID 11737393 | — |
| 반응물 | 1-(Phenylsulfonyl)-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyrrolo[2,3-b]pyridine | HCID 45588137 | — |
| 촉매 | HCID 178418476 | HCID 178418476 | — |
| 용매 | Dimethoxyethane ethanol water | HCID 86587095 | — |
| 생성물 | 3-(2,6-dichloropyridin-4-yl)-1-(phenylsulfonyl)-1H-pyrrolo[2,3-b]pyridine | HCID 86649869 | 90% |
반응 단계
A suspension of 1-(phenylsulfonyl)-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrrolo[2,3-b]pyridine (4.63 g, 12.1 mmol), 2,6-dichloro-4-iodopyridine (3.00 g, 11.0 mmol), dichlorobis(triphenylphosphine)palladium(II) (0.308 g, 0.438 mmol) and sodium carbonate (1M, 8.76 mL, 8.76 mmol) in 1,2-dimethoxyethane/ethanol/water (7:2:3) (30 mL) was degassed and heated at 80° C. overnight. After cooling, the suspension was diluted with ethyl acetate, filtered, washed with ethyl acetate and water, and oven-dried to give 3.98 g (90%) of the title compound.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| 특허 번호 | US08435980B2 |
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| 출처 데이터셋 | uspto-grants-2013_05 |
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| ORD ID | ord-0484f239b7324b32b53fe5b0656f7f28 |
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| 출처 메모 | uspto-grants-2013_05 |
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