Potassium Hydroxide → HCID 87191335, 화합물

HRID 2089002

반응식

HRID 2089002 반응식
[Cl:1][C:2]1[CH:7]=[C:6]([C:8]2[C:16]3[C:11](=[N:12][CH:13]=[CH:14][CH:15]=3)[N:10](S(C3C=CC=CC=3)(=O)=O)[CH:9]=2)[CH:5]=[C:4]([Cl:26])[N:3]=1.[OH-].[K+]>C(O)C.O>[Cl:26][C:4]1[CH:5]=[C:6]([C:8]2[C:16]3[C:11](=[N:12][CH:13]=[CH:14][CH:15]=3)[NH:10][CH:9]=2)[CH:7]=[C:2]([Cl:1])[N:3]=1

참가 물질

4

반응물 2

HCID 14797Potassium HydroxideHCID 866498693-(2,6-dichloropyridin-4-yl)-1-(phenylsulfonyl)-1H-pyrrolo[2,3-b]pyridine

생성물 1

HCID 87191335HCID 87191335, 화합물수율 88.3%

시약·촉매·용매 1

HCID 19096565Water ethanol용매

반응 조건

온도
40 °C

실험 절차

To a solution of Example 7a (5.72 g, 15 mmol) in 60 mL ethanol/water (5/1) was added powdered KOH (2 g, 35 mmol). The resulting solution was heated at 40° C. for 2 hours. Most of the solvent was removed in vacuo, and the residue was diluted with ethyl acetate. A solid was filtered from the material and discarded. The organics were washed with water, brine, dried over MgSO4, filtered, and concentrated. The crude material was triturated with dichloromethane and filtered, giving 3.5 g of the title compound as a white solid. MS (ESI+) m/z 263.6 (M+H)+.

후처리

  1. customMost of the solvent was removed in vacuo
  2. additionthe residue was diluted with ethyl acetate
  3. filtrationA solid was filtered from the material
  4. washThe organics were washed with water, brine
  5. dry with materialdried over MgSO4
  6. filtrationfiltered
  7. concentrationconcentrated
  8. customThe crude material was triturated with dichloromethane
  9. filtrationfiltered

출처 및 근거

ORD 기록
ord-dbe488fa85d8415a9d7ac19307942f55
출처 데이터셋
uspto-grants-2013_05
특허 번호
US08435980B2

연결된 노트

불러오는 중…