Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
HRID 2089007생성일: 2026년 10월 25일
Acetamide → N-(6-chloro-4-(1-(phenylsulfonyl)-1H-pyrrolo[2,3-b]pyridin-3-yl)pyridin-2-yl)acetamide
https://huagongshe.com/reaction/2089007
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | Acetamide | HCID 178 | — |
| 반응물 | Cesium carbonate | HCID 10796 | — |
| 반응물 | 1,1'-(9,9-Dimethyl-9H-xanthene-4,5-diyl)bis(1,1-diphenylphosphine) | HCID 636044 | — |
| 반응물 | 3-(2,6-dichloropyridin-4-yl)-1-(phenylsulfonyl)-1H-pyrrolo[2,3-b]pyridine | HCID 86649869 | — |
| 촉매 | palladium(II) acetate | HCID 167845 | — |
| 생성물 | N-(6-chloro-4-(1-(phenylsulfonyl)-1H-pyrrolo[2,3-b]pyridin-3-yl)pyridin-2-yl)acetamide | HCID 87192560 | 25.2% |
반응 단계
A mixture of Example 7a (1.44 g, 3.57 mmol), acetamide (0.295 g, 4.99 mmol), cesium carbonate (1.743 g, 5.35 mmol), palladium (II) acetate (0.024 g, 0.107 mmol), and Xantphos (0.093 g, 0.161 mmol) was degassed and heated at 85° C. in a sealed vial for 6 hours. The reaction mixture was cooled and concentrated. The residue was treated with 20% brine and extracted with EtOAc (2×). The organic layers were dried, concentrated, and purified on a 40 g column using the ISCO Companion flash system eluting with CH2Cl2/EtOAc (90:10) to give 0.384 g of the title compound.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| 특허 번호 | US08435980B2 |
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| 출처 데이터셋 | uspto-grants-2013_05 |
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| ORD ID | ord-9cf9dd06848645bfa34fc70ecf343d49 |
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| 출처 메모 | uspto-grants-2013_05 |
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