Triethylamine → N-(3-(6-chloro-4-iodopyridin-2-ylamino)cyclohexyl)-2-(1,3-dioxoisoindolin-2-yl)ethanesulfonamide

HRID 2089015

반응식

HRID 2089015 반응식
[Cl:1][C:2]1[N:7]=[C:6]([NH:8][CH:9]2[CH2:14][CH2:13][CH2:12][CH:11]([NH2:15])[CH2:10]2)[CH:5]=[C:4]([I:16])[CH:3]=1.C(N(CC)CC)C.[O:24]=[C:25]1[C:33]2[C:28](=[CH:29][CH:30]=[CH:31][CH:32]=2)[C:27](=[O:34])[N:26]1[CH2:35][CH2:36][S:37](Cl)(=[O:39])=[O:38]>C(Cl)Cl>[Cl:1][C:2]1[N:7]=[C:6]([NH:8][CH:9]2[CH2:14][CH2:13][CH2:12][CH:11]([NH:15][S:37]([CH2:36][CH2:35][N:26]3[C:25](=[O:24])[C:33]4[C:28](=[CH:29][CH:30]=[CH:31][CH:32]=4)[C:27]3=[O:34])(=[O:38])=[O:39])[CH2:10]2)[CH:5]=[C:4]([I:16])[CH:3]=1

참가 물질

5

반응물 3

HCID 8471TriethylamineHCID 3087392-Phthalimidoethanesulfonyl chlorideHCID 86649873N1-(6-chloro-4-iodopyridin-2-yl)cyclohexane-1,3-diamine

생성물 1

HCID 87192629N-(3-(6-chloro-4-iodopyridin-2-ylamino)cyclohexyl)-2-(1,3-dioxoisoindolin-2-yl)ethanesulfonamide

시약·촉매·용매 1

HCID 6344Dichloromethane용매

실험 절차

To a solution of Example 145a (280 mg, 0.8 mmol) in CH2Cl2 (10 mL) was added triethylamine (110 mg, 1 mmol) and followed by 2-(1,3-dioxoisoindolin-2-yl)ethanesulfonyl chloride (262 mg, 0.95 mmol). The mixture was stirred at room temperature overnight. The reaction mixture was concentrated and the residue was purified by flash chromophatography (EtOAc/hexanes=1:4) to give the title compound. Yield: 180 mg (32%). MS (DCI/NH3) m/z 589 (M+H)+.

후처리

  1. concentrationThe reaction mixture was concentrated
  2. customthe residue was purified by flash chromophatography (EtOAc/hexanes=1:4)

출처 및 근거

ORD 기록
ord-b2c476efba3c49d692f80289dff4f3d9
출처 데이터셋
uspto-grants-2013_05
특허 번호
US08435980B2

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