Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
HRID 2089017생성일: 2026년 10월 25일
Sodium Carbonate → 3-(2,6-dichloropyridin-4-yl)-5-methoxy-1-(phenylsulfonyl)-1H-pyrrolo[2,3-b]pyridine
https://huagongshe.com/reaction/2089017
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | Sodium Carbonate | HCID 10340 | — |
| 반응물 | 2,6-Dichloro-4-iodopyridine | HCID 11737393 | — |
| 반응물 | 5-Methoxy-1-(phenylsulfonyl)-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrrolo[2,3-b]pyridine | HCID 66889277 | — |
| 촉매 | HCID 178418476 | HCID 178418476 | — |
| 용매 | Water | HCID 962 | — |
| 용매 | Dimethoxyethane ethanol water | HCID 86587095 | — |
| 생성물 | 3-(2,6-dichloropyridin-4-yl)-5-methoxy-1-(phenylsulfonyl)-1H-pyrrolo[2,3-b]pyridine | HCID 87192554 | 56% |
반응 단계
A suspension of Example 149c (0.150 g, 0.362 mmol), 2,6-dichloro-4-iodopyridine (0.099 g, 0.362 mmol), dichlorobis(triphenylphosphine)palladium(II) (10.17 mg, 0.014 mmol) and 1M sodium carbonate (0.290 mL, 0.290 mmol) in dimethoxyethane/EtOH/water (7:2:3, 2.5 mL) was degassed and heated at 80° C. overnight. After cooling, the suspension was diluted with water and extracted with EtOAc (2×). The suspension in the aq. layer was filtered, washed with water, and dried to give 88.0 mg of the title compound
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| 특허 번호 | US08435980B2 |
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| 출처 데이터셋 | uspto-grants-2013_05 |
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| ORD ID | ord-18cb2881cc434b15bb93ad7040602c4b |
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| 출처 메모 | uspto-grants-2013_05 |
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