Potassium Hydroxide → 3-(2,6-Dichloro-4-pyridinyl)-5-methoxy-1H-pyrrolo[2,3-b]pyridine

HRID 2089018

반응식

HRID 2089018 반응식
[Cl:1][C:2]1[CH:7]=[C:6]([C:8]2[C:16]3[C:11](=[N:12][CH:13]=[C:14]([O:17][CH3:18])[CH:15]=3)[N:10](S(C3C=CC=CC=3)(=O)=O)[CH:9]=2)[CH:5]=[C:4]([Cl:28])[N:3]=1.[OH-].[K+]>C(O)C.O>[Cl:1][C:2]1[CH:7]=[C:6]([C:8]2[C:16]3[C:11](=[N:12][CH:13]=[C:14]([O:17][CH3:18])[CH:15]=3)[NH:10][CH:9]=2)[CH:5]=[C:4]([Cl:28])[N:3]=1

참가 물질

5

반응물 2

HCID 14797Potassium HydroxideHCID 871925543-(2,6-dichloropyridin-4-yl)-5-methoxy-1-(phenylsulfonyl)-1H-pyrrolo[2,3-b]pyridine

생성물 1

HCID 871921833-(2,6-Dichloro-4-pyridinyl)-5-methoxy-1H-pyrrolo[2,3-b]pyridine수율 85.9%

시약·촉매·용매 2

HCID 702Ethanol용매HCID 962Water용매

반응 조건

온도
50 °C

실험 절차

A suspension of Example 149d (88.0 mg, 0.203 mmol) in ethanol (2 mL) was treated with a solution of potassium hydroxide (45.5 mg, 0.811 mmol) in water (0.5 mL). The reaction mixture was heated at 50° C. for 1.5 hours. After concentration, water was added to the residue and the mixture was sonicated. The solid was filtered, washed with water, and oven-dried to give 51.3 mg of the title compound.

후처리

  1. concentrationAfter concentration, water
  2. additionwas added to the residue
  3. customthe mixture was sonicated
  4. filtrationThe solid was filtered
  5. washwashed with water
  6. customoven-dried

출처 및 근거

ORD 기록
ord-e69bb49baf794e34b733545ae9b2740b
출처 데이터셋
uspto-grants-2013_05
특허 번호
US08435980B2

연결된 노트

불러오는 중…