1,3-Cyclohexanediamine → N1-(6-chloro-4-iodopyridin-2-yl)cyclohexane-1,3-diamine

HRID 2089054

반응식

HRID 2089054 반응식
Cl[C:2]1[CH:7]=[C:6]([I:8])[CH:5]=[C:4]([Cl:9])[N:3]=1.[CH:10]1([NH2:17])[CH2:15][CH2:14][CH2:13][CH:12]([NH2:16])[CH2:11]1>CCOC(C)=O>[Cl:9][C:4]1[N:3]=[C:2]([NH:16][CH:12]2[CH2:13][CH2:14][CH2:15][CH:10]([NH2:17])[CH2:11]2)[CH:7]=[C:6]([I:8])[CH:5]=1

참가 물질

4

반응물 2

HCID 188141,3-CyclohexanediamineHCID 117373932,6-Dichloro-4-iodopyridine

생성물 1

HCID 86649873N1-(6-chloro-4-iodopyridin-2-yl)cyclohexane-1,3-diamine수율 81.6%

시약·촉매·용매 1

HCID 8857Ethyl Acetate용매

반응 조건

온도
120 °C

실험 절차

A mixture of 2,6-dichloro-4-iodopyridine (2.500 g, 9.13 mmol) and cyclohexane-1,3-diamine (4.44 mL, 36.5 mmol) was heated at 120° C. in a capped vial for 2 hours. While warm, the reaction mixture was treated with EtOAc and washed with water (3×). The organic layer was dried and concentrated to give 2.62 g of the crude title compound. This material was carried into the next step without further purification.

후처리

  1. temperatureWhile warm
  2. washwashed with water (3×)
  3. customThe organic layer was dried
  4. concentrationconcentrated

출처 및 근거

ORD 기록
ord-15d5311746fd4a30bcf218795ee4523d
출처 데이터셋
uspto-grants-2013_05
특허 번호
US08435980B2

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