Triethylamine → N-(3-(6-chloro-4-iodopyridin-2-ylamino)cyclohexyl)cyclopropanesulfonamide

HRID 2089055

반응식

HRID 2089055 반응식
[Cl:1][C:2]1[N:7]=[C:6]([NH:8][CH:9]2[CH2:14][CH2:13][CH2:12][CH:11]([NH2:15])[CH2:10]2)[CH:5]=[C:4]([I:16])[CH:3]=1.C(N(CC)CC)C.[CH:24]1([S:27](Cl)(=[O:29])=[O:28])[CH2:26][CH2:25]1>CN(C=O)C>[Cl:1][C:2]1[N:7]=[C:6]([NH:8][CH:9]2[CH2:14][CH2:13][CH2:12][CH:11]([NH:15][S:27]([CH:24]3[CH2:26][CH2:25]3)(=[O:29])=[O:28])[CH2:10]2)[CH:5]=[C:4]([I:16])[CH:3]=1

참가 물질

5

반응물 3

HCID 8471TriethylamineHCID 2760919Cyclopropanesulfonyl chlorideHCID 86649873N1-(6-chloro-4-iodopyridin-2-yl)cyclohexane-1,3-diamine

생성물 1

HCID 87191790N-(3-(6-chloro-4-iodopyridin-2-ylamino)cyclohexyl)cyclopropanesulfonamide수율 22.2%

시약·촉매·용매 1

HCID 6228Dimethylformamide용매

실험 절차

To a solution of Example 260a (0.320 g, 0.910 mmol) in DMF (6 mL) were added triethylamine (0.165 mL, 1.183 mmol) and cyclopropanesulfonyl chloride (0.102 mL, 1.001 mmol). The reaction mixture was stirred at room temperature overnight, quenched with brine and NaHCO3 and extracted with EtOAc. The organic layer was dried over MgSO4, filtered, concentrated, and purified on a 40 g column using the ISCO Companion flash system eluting with hexane/EtOAc (7:3 to 1:1) to give 0.092 g of the title compound.

후처리

  1. customquenched with brine and NaHCO3
  2. extractionextracted with EtOAc
  3. dry with materialThe organic layer was dried over MgSO4
  4. filtrationfiltered
  5. concentrationconcentrated
  6. custompurified on a 40 g column
  7. washeluting with hexane/EtOAc (7:3 to 1:1)

출처 및 근거

ORD 기록
ord-1812198d119c44dfbd88a853247dc70f
출처 데이터셋
uspto-grants-2013_05
특허 번호
US08435980B2

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