Water → 2-methyl-2,3,5,6,7,8-hexahydro-1H-cyclopenta[b]naphthalen-1-one

HRID 2089085노트

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HRID 2089085 반응식
[CH:1]1[CH2:2][C:3](=O)[CH:4]=[C:5]2[C:10]=1[CH:9]=[CH:8][CH:7]=[CH:6]2.[OH2:12]>>[CH3:4][CH:5]1[C:10](=[O:12])[C:2]2=[CH:1][C:10]3[CH2:9][CH2:8][CH2:7][CH2:6][C:5]=3[CH:4]=[C:3]2[CH2:6]1

참가 물질

3

반응물 2

HCID 962WaterHCID 20192716Naphthalen-3-one

생성물 1

HCID 224992222-methyl-2,3,5,6,7,8-hexahydro-1H-cyclopenta[b]naphthalen-1-one

실험 절차

The reaction is diluted with water and extracted with dichloromethane. After drying (Na2SO4) the solvent is removed to give an oil. The product is purified by chromatography (silica, ethyl acetate/hexane) to give a geometrical mixture of isomers containing 2-Methyl-1,2,6,7,8,9-hexahydro-cyclopenta[.a.]naphthalen-3-one and the title compound.

후처리

  1. extractionextracted with dichloromethane
  2. dry with materialAfter drying (Na2SO4) the solvent
  3. customis removed
  4. customto give an oil
  5. customThe product is purified by chromatography (silica, ethyl acetate/hexane)
  6. customto give
  7. additiona geometrical mixture of isomers
  8. additioncontaining 2-Methyl-1,2,6,7,8,9-hexahydro-cyclopenta[.a

출처 및 근거

ORD 기록
ord-f6363a541244451d9f99629d4227ec76
출처 데이터셋
uspto-grants-2013_05
특허 번호
US08436017B2

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