Allyl bromide → 2-(1-Allyl-5-trifluoromethyl-1H-indazol-3-yl)-isoindole-1,3-dione

HRID 2089230

반응식

HRID 2089230 반응식
[F:1][C:2]([F:24])([F:23])[C:3]1[CH:4]=[C:5]2[C:9](=[CH:10][CH:11]=1)[NH:8][N:7]=[C:6]2[N:12]1[C:20](=[O:21])[C:19]2[C:14](=[CH:15][CH:16]=[CH:17][CH:18]=2)[C:13]1=[O:22].C([O-])([O-])=O.[K+].[K+].[CH2:31](Br)[CH:32]=[CH2:33]>CC(C)=O>[CH2:33]([N:8]1[C:9]2[C:5](=[CH:4][C:3]([C:2]([F:23])([F:1])[F:24])=[CH:11][CH:10]=2)[C:6]([N:12]2[C:20](=[O:21])[C:19]3[C:14](=[CH:15][CH:16]=[CH:17][CH:18]=3)[C:13]2=[O:22])=[N:7]1)[CH:32]=[CH2:31]

참가 물질

5

반응물 3

HCID 7841Allyl bromideHCID 11430Potassium CarbonateHCID 585488622-(5-Trifluoromethyl-1H-indazol-3-yl)-isoindole-1,3-dione

생성물 1

HCID 585488592-(1-Allyl-5-trifluoromethyl-1H-indazol-3-yl)-isoindole-1,3-dione

시약·촉매·용매 1

HCID 180Acetone용매

실험 절차

2-(5-Trifluoromethyl-1H-indazol-3-yl)-isoindole-1,3-dione (500 mg, 1.51 mmol), K2CO3 (313 mg, 2.26 mmol) and allyl bromide (365 mg, 3.02 mmol) in acetone (10 mL) were heated to reflux overnight. The reaction was filtered, and the residue was concentrated and purified by silica gel column chromatography using hexanes:ethyl acetate 2:1 to give the title compound as white solid.

후처리

  1. temperatureto reflux overnight
  2. filtrationThe reaction was filtered
  3. concentrationthe residue was concentrated
  4. custompurified by silica gel column chromatography

출처 및 근거

ORD 기록
ord-bb13fa88d3624b88a62ae5e32cab2fb9
출처 데이터셋
uspto-grants-2013_05
특허 번호
US08436023B2

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