1-Propanesulfonic acid → 3-methoxy-2,2-dimethylpropionic acid 5-[(R)-[3-(2-acetoxyethoxy)-2-fluoro-5-methoxyphenyl]-(4-{amino[2-methylallyloxycarbonylimino]methyl}-phenylamino)methyl]-2-pyrimidin-2-yl-2H-[1,2,4]triazol-3-yloxymethyl ester propanesulfonate

HRID 2089674

반응식

HRID 2089674 반응식
[C:1]([O:4][CH2:5][CH2:6][O:7][C:8]1[C:9]([F:56])=[C:10]([C@@H:16]([NH:39][C:40]2[CH:45]=[CH:44][C:43]([C:46]([NH2:55])=[N:47][C:48]([O:50][CH2:51][C:52]([CH3:54])=[CH2:53])=[O:49])=[CH:42][CH:41]=2)[C:17]2[N:18]=[C:19]([O:28][CH2:29][O:30][C:31](=[O:38])[C:32]([CH3:37])([CH3:36])[CH2:33][O:34][CH3:35])[N:20]([C:22]3[N:27]=[CH:26][CH:25]=[CH:24][N:23]=3)[N:21]=2)[CH:11]=[C:12]([O:14][CH3:15])[CH:13]=1)(=[O:3])[CH3:2].[CH2:57]([S:60]([OH:63])(=[O:62])=[O:61])[CH2:58][CH3:59]>C(OCC)(=O)C>[CH2:57]([S:60]([OH:63])(=[O:62])=[O:61])[CH2:58][CH3:59].[C:1]([O:4][CH2:5][CH2:6][O:7][C:8]1[C:9]([F:56])=[C:10]([C@@H:16]([NH:39][C:40]2[CH:41]=[CH:42][C:43]([C:46]([NH2:55])=[N:47][C:48]([O:50][CH2:51][C:52]([CH3:54])=[CH2:53])=[O:49])=[CH:44][CH:45]=2)[C:17]2[N:18]=[C:19]([O:28][CH2:29][O:30][C:31](=[O:38])[C:32]([CH3:37])([CH3:36])[CH2:33][O:34][CH3:35])[N:20]([C:22]3[N:27]=[CH:26][CH:25]=[CH:24][N:23]=3)[N:21]=2)[CH:11]=[C:12]([O:14][CH3:15])[CH:13]=1)(=[O:3])[CH3:2]

참가 물질

4

반응물 2

HCID 789381-Propanesulfonic acidHCID 674711843-methoxy-2,2-dimethylpropionic acid 5-[(R)-[3-(2-acetoxyethoxy)-2-fluoro-5-methoxyphenyl]-(4-{amino[2-methylallyloxycarbonylimino]methyl}phenylamino)methyl]-2-pyrimidin-2-yl-2H-[1,2,4]triazol-3-yloxymethyl ester

생성물 1

HCID 866774063-methoxy-2,2-dimethylpropionic acid 5-[(R)-[3-(2-acetoxyethoxy)-2-fluoro-5-methoxyphenyl]-(4-{amino[2-methylallyloxycarbonylimino]methyl}-phenylamino)methyl]-2-pyrimidin-2-yl-2H-[1,2,4]triazol-3-yloxymethyl ester propanesulfonate

시약·촉매·용매 1

HCID 8857Ethyl Acetate용매2회

실험 절차

At room temperature, 3-methoxy-2,2-dimethylpropionic acid 5-[(R)-[3-(2-acetoxyethoxy)-2-fluoro-5-methoxyphenyl]-(4-{amino[2-methylallyloxycarbonylimino]methyl}phenylamino)methyl]-2-pyrimidin-2-yl-2H-[1,2,4]triazol-3-yloxymethyl ester (Example 6f, 100 mg) was dissolved in ethyl acetate (10 mL), a solution of 1-propanesulfonic acid [CAS No. 5284-66-2] (13.5 mg) in ethyl acetate (1 mL) was added dropwise thereto. The resulting mixture was stirred at room temperature for 22 hours, and the precipitated solid was filtered. The solids recovered by filtration were washed with ethyl acetate and TBME, and dried. The captioned compound (90 mg) was obtained.

후처리

  1. filtrationthe precipitated solid was filtered
  2. filtrationThe solids recovered by filtration
  3. washwere washed with ethyl acetate and TBME
  4. customdried

출처 및 근거

ORD 기록
ord-2e44d4a1045040d58a204d93b19e7e9b
출처 데이터셋
uspto-grants-2013_05
특허 번호
US08436009B2

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