Chloroacetyl chloride → HCID 68432292, 화합물

HRID 2090245노트

반응식

HRID 2090245 반응식
[Cl:1][CH2:2][C:3](Cl)=[O:4].[NH2:6][C:7]1[C:16]2[N:17]=[C:18]([CH2:36][O:37][CH2:38][CH3:39])[N:19]([CH2:20][CH2:21][CH2:22][NH:23][CH2:24][C:25]3[CH:26]=[C:27]([CH2:31][C:32]([O:34][CH3:35])=[O:33])[CH:28]=[CH:29][CH:30]=3)[C:15]=2[C:14]2[CH:13]=[CH:12][CH:11]=[CH:10][C:9]=2[N:8]=1>CC#N>[NH2:6][C:7]1[C:16]2[N:17]=[C:18]([CH2:36][O:37][CH2:38][CH3:39])[N:19]([CH2:20][CH2:21][CH2:22][N:23]([CH2:24][C:25]3[CH:26]=[C:27]([CH2:31][C:32]([O:34][CH3:35])=[O:33])[CH:28]=[CH:29][CH:30]=3)[C:3](=[O:4])[CH2:2][Cl:1])[C:15]=2[C:14]2[CH:13]=[CH:12][CH:11]=[CH:10][C:9]=2[N:8]=1

참가 물질

4

반응물 2

HCID 6577Chloroacetyl chlorideHCID 68430759HCID 68430759, 화합물

생성물 1

HCID 68432292HCID 68432292, 화합물

시약·촉매·용매 1

HCID 6342Acetonitrile용매

실험 절차

Chloroacetyl chloride (0.059 mL) was added to the product of step (v) (25 mg) in MeCN (2 mL) at rt under nitrogen. The resulting solution was stirred at rt for 2 h, then concentrated in vacuo and azeotroped with toluene, yield 30 mg.

후처리

  1. concentrationconcentrated in vacuo
  2. customazeotroped with toluene, yield 30 mg

출처 및 근거

ORD 기록
ord-5e6b2356fab54371bb3ddfddb3bc2933
출처 데이터셋
uspto-grants-2013_05
특허 번호
US08436178B2

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