Dimethylamine → HCID 25106689, 화합물

HRID 2090246노트

반응식

HRID 2090246 반응식
[NH2:1][C:2]1[C:11]2[N:12]=[C:13]([CH2:35][O:36][CH2:37][CH3:38])[N:14]([CH2:15][CH2:16][CH2:17][N:18]([CH2:23][C:24]3[CH:25]=[C:26]([CH2:30][C:31]([O:33][CH3:34])=[O:32])[CH:27]=[CH:28][CH:29]=3)[C:19](=[O:22])[CH2:20]Cl)[C:10]=2[C:9]2[CH:8]=[CH:7][CH:6]=[CH:5][C:4]=2[N:3]=1.[CH3:39][NH:40][CH3:41]>CN(C=O)C>[CH3:34][O:33][C:31](=[O:32])[CH2:30][C:26]1[CH:27]=[CH:28][CH:29]=[C:24]([CH2:23][N:18]([CH2:17][CH2:16][CH2:15][N:14]2[C:10]3[C:9]4[CH:8]=[CH:7][CH:6]=[CH:5][C:4]=4[N:3]=[C:2]([NH2:1])[C:11]=3[N:12]=[C:13]2[CH2:35][O:36][CH2:37][CH3:38])[C:19](=[O:22])[CH2:20][N:40]([CH3:41])[CH3:39])[CH:25]=1

참가 물질

4

반응물 2

HCID 674DimethylamineHCID 68432292HCID 68432292, 화합물

생성물 1

HCID 25106689HCID 25106689, 화합물

시약·촉매·용매 1

HCID 6228Dimethylformamide용매

실험 절차

The product from step (vi) (30 mg) was dissolved in DMF (2 mL) then a solution of dimethylamine (2M in THF, 0.279 mL) was added at rt under nitrogen. The resulting solution was stirred at rt for 16 h. The mixture was purified by RPHPLC to give the title compound, yield 4.5 mg.

후처리

  1. customThe mixture was purified by RPHPLC

출처 및 근거

ORD 기록
ord-fce58ec914cd4d119d2ac232c5bdee8a
출처 데이터셋
uspto-grants-2013_05
특허 번호
US08436178B2

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