Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
2-(4-Methylpiperazin-1-yl)pyridine-4-boronic acid, pinacol ester → 4-(4-Methylpiperazin-1-yl)-6-[7-[2-(4-methylpiperazin-1-yl)pyridin-4-yl]-3,4-dihydroisoquinolin-2(1H)-yl]pyrimidin-2-amine
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | 2-(4-Methylpiperazin-1-yl)pyridine-4-boronic acid, pinacol ester | HCID 2769537 | — |
| 반응물 | 4-(7-bromo-3,4-dihydroisoquinolin-2(1H)-yl)-6-(4-methylpiperazin-1-yl)pyrimidin-2-amine | HCID 46701048 | — |
| 생성물 | 4-(4-Methylpiperazin-1-yl)-6-[7-[2-(4-methylpiperazin-1-yl)pyridin-4-yl]-3,4-dihydroisoquinolin-2(1H)-yl]pyrimidin-2-amine | HCID 59402302 | — |
반응 단계
This compound was prepared by using procedures analogous to those described for the synthesis of Example 2 starting from 4-(7-bromo-3,4-dihydroisoquinolin-2(1H)-yl)-6-(4-methylpiperazin-1-yl)pyrimidin-2-amine and 1-methyl-4-[4(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridin-2-yl]piperazine (Oadwood, Cat. No. 021854). LCMS (M+H)+: m/z=500.5.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US08436008B2 |
| 출처 데이터셋 | uspto-grants-2013_05 |
| ORD ID | ord-f77c56a60ce244b8a6de209918a5af26 |
| 출처 메모 | uspto-grants-2013_05 |