Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
4-Phenylpiperidin-4-ol → 1-{2-[2-Amino-6-(4-methylpiperazin-1-yl)pyrimidin-4-yl]-1,2,3,4-tetrahydroisoquinolin-7-yl}-4-phenylpiperidin-4-ol
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | 4-Phenylpiperidin-4-ol | HCID 96387 | — |
| 반응물 | 4-(7-bromo-3,4-dihydroisoquinolin-2(1H)-yl)-6-(4-methylpiperazin-1-yl)pyrimidin-2-amine | HCID 46701048 | — |
| 생성물 | 1-{2-[2-Amino-6-(4-methylpiperazin-1-yl)pyrimidin-4-yl]-1,2,3,4-tetrahydroisoquinolin-7-yl}-4-phenylpiperidin-4-ol | HCID 46701463 | — |
반응 단계
This compound was prepared by using procedures analogous to those described for the synthesis of Example 36 starting from 4-(7-bromo-3,4-dihydroisoquinolin-2(1H)-yl)-6-(4-methylpiperazin-1-yl)pyrimidin-2-amine and 4-hydroxy-4-phenylpiperidine (Aldrich Cat. No. H52201). LCMS (M+H)+: m/z=500.3.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US08436008B2 |
| 출처 데이터셋 | uspto-grants-2013_05 |
| ORD ID | ord-a8c983a325c24c8cba1991c3dfc4ce8f |
| 출처 메모 | uspto-grants-2013_05 |