3-(Dimethylamino)pyrrolidine → 4-[7-(5-{[3-(Dimethylamino)pyrrolidin-1-yl]carbonyl}-1-methyl-1H-pyrrol-3-yl)-3-methyl-3,4-dihydroisoquinolin-2(1H)-yl]-6-(4-methylpiperazin-1-yl)pyrimidin-2-amine

HRID 2090406노트

반응식

HRID 2090406 반응식
[NH2:1][C:2]1[N:7]=[C:6]([N:8]2[CH:17]([CH3:18])[CH2:16][C:15]3[C:10](=[CH:11][C:12]([C:19]4[CH:20]=[C:21]([C:25](O)=[O:26])[N:22]([CH3:24])[CH:23]=4)=[CH:13][CH:14]=3)[CH2:9]2)[CH:5]=[C:4]([N:28]2[CH2:33][CH2:32][N:31]([CH3:34])[CH2:30][CH2:29]2)[N:3]=1.[CH3:35][N:36]([CH3:42])[CH:37]1[CH2:41][CH2:40][NH:39][CH2:38]1>>[CH3:35][N:36]([CH3:42])[CH:37]1[CH2:41][CH2:40][N:39]([C:25]([C:21]2[N:22]([CH3:24])[CH:23]=[C:19]([C:12]3[CH:11]=[C:10]4[C:15]([CH2:16][CH:17]([CH3:18])[N:8]([C:6]5[CH:5]=[C:4]([N:28]6[CH2:29][CH2:30][N:31]([CH3:34])[CH2:32][CH2:33]6)[N:3]=[C:2]([NH2:1])[N:7]=5)[CH2:9]4)=[CH:14][CH:13]=3)[CH:20]=2)=[O:26])[CH2:38]1

참가 물질

3

반응물 2

HCID 27585193-(Dimethylamino)pyrrolidineHCID 59402268HCID 59402268, 화합물

생성물 1

HCID 467009804-[7-(5-{[3-(Dimethylamino)pyrrolidin-1-yl]carbonyl}-1-methyl-1H-pyrrol-3-yl)-3-methyl-3,4-dihydroisoquinolin-2(1H)-yl]-6-(4-methylpiperazin-1-yl)pyrimidin-2-amine

실험 절차

This compound was prepared by using procedures analogous to those described for the synthesis of Example 87A, Step 9 starting from 4-{2-[2-Amino-6-(4-methylpiperazin-1-yl)pyrimidin-4-yl]-3-methyl-1,2,3,4-tetrahydroisoquinolin-7-yl}-1-methyl-1H-pyrrole-2-carboxylic acid (Example 87A, Step 8) and N,N-dimethylpyrrolidin-3-amine. LCMS (M+H)+: m/z=558.3.

후처리

  1. customThis compound was prepared

출처 및 근거

ORD 기록
ord-4a00165b0685464584f7d297adddfae9
출처 데이터셋
uspto-grants-2013_05
특허 번호
US08436008B2

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