Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Sodium hydride → 1-(2-Chloropyrimidin-5-ylsulfonyl)-5-phenyl-1H-pyrrole-3-carbaldehyde
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Sodium hydride | HCID 24758 | — |
| 반응물 | 15-Crown-5 | HCID 36336 | — |
| 반응물 | 5-Phenyl-1H-pyrrole-3-carboxaldehyde | HCID 11052090 | — |
| 반응물 | 2-Chloropyrimidine-5-sulfonyl chloride | HCID 43244366 | — |
| 생성물 | 1-(2-Chloropyrimidin-5-ylsulfonyl)-5-phenyl-1H-pyrrole-3-carbaldehyde | HCID 86620758 | — |
반응 단계
By a reaction under similar conditions as in Reference Example 55 and using 5-phenyl-1H-pyrrole-3-carbaldehyde (342 mg), sodium hydride (60% in oil, 120 mg), 15-crown-5 (0.60 mL) and 2-chloro-5-pyrimidinesulfonyl chloride (554 mg), the title compound was obtained as a yellow solid (yield 390 mg, 56%).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US08436187B2 |
| 출처 데이터셋 | uspto-grants-2013_05 |
| ORD ID | ord-331aa2e0777040e5905244e696de091e |
| 출처 메모 | uspto-grants-2013_05 |