[F:1][C:2]([F:15])([F:14])[C:3]1[CH:4]=[CH:5][C:6]2[N:7]([CH:9]=[C:10]([CH:12]=[O:13])[N:11]=2)[CH:8]=1.[CH:16]1([Mg]Br)[CH2:21][CH2:20][CH2:19][CH2:18][CH2:17]1.[Cl-].[NH4+]>O1CCCC1>[CH:16]1([CH:12]([C:10]2[N:11]=[C:6]3[CH:5]=[CH:4][C:3]([C:2]([F:1])([F:14])[F:15])=[CH:8][N:7]3[CH:9]=2)[OH:13])[CH2:21][CH2:20][CH2:19][CH2:18][CH2:17]1To a solution of 6-(trifluoromethyl)imidazo[1,2-a]pyridine-2-carbaldehyde (2.1 g) synthesized above in tetrahydrofuran (40 mL) was added dropwise cyclohexylmagnesium bromide (1M tetrahydrofuran solution, 15 mL) at 0° C. After stirring at 0° C. for 1 hr, aqueous ammonium chloride solution was added. The mixture was extracted with ethyl acetate, and the solvent was evaporated under reduced pressure. The precipitate was washed with ethanol-diisopropyl ether to give the title object compound (0.9 g, 30%) as a colorless solid.
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